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YCS22· Other

Cisterna Biologics

High quality mRNA for therapeutic application

ActiveChecked 20h ago
Batch
S22
Status, per YC
Active
Team size
2
HQ
San Diego, CA
In S22233 companies, 55% AI
cisternabx.comYC profile

Founders

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About Cisterna Biologics

Founded in 2022 and based in San Diego, California, Cisterna Biologics is a technology company. It aims to solve some of the challenges currently facing the biotech industry to develop mRNA-based therapeutics – quality, quantity, longevity and cost of mRNA. As mRNA technology matures, it becomes imperative that these issues are solved so we can fully explore mRNA's endless possibilities as a therapeutic. Cisterna uses proprietary technologies to either remove a contaminant at its source or replace the source itself. For example, to remove double-stranded RNA (dsRNA), we use ribozymes - molecular scissors - to precisely cut the mRNA at its 3’ end. This assures not only 3’ homogeneity, but also eliminates dsRNA, which are primarily produced due to self-templated additions at the 3’ end. Utilizing a PCR-like system to amplify the DNA template in large quantities eliminates the requirement for plasmid enrichment in bacteria, the prime source of endotoxin contamination. These are just a few examples of Cisterna’s powerful technologies being used to achieve our goal of 10x higher quality mRNA for therapeutic application.

San Diego, CA, USA

Cisterna Biologics: questions

Which YC batch was Cisterna Biologics in?

Cisterna Biologics was in Y Combinator's Summer 2022 batch (S22).

Is Cisterna Biologics still active?

Y Combinator lists Cisterna Biologics as active.

Where is Cisterna Biologics based?

Cisterna Biologics lists San Diego, CA, USA as its location on YC's directory.

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